Early sign of depression by RxDx | May 14, 2014 | Blog, Educating the community, Patient to Patient, Psychiatry, Psychology Early sign of depression in males or young adults 1. Lack of sleep 2. Irritability 3. Loss of appetite 4. Lethargy Subscribe to our Newsletter * indicates required Email Address * For booking, appointment call us today!!! If you have further questions then please contact us on.